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Modelling primary blast lung injury: current capability and future direction
  1. Timothy Scott1,
  2. E Hulse1,
  3. M Haque2,
  4. E Kirkman3,
  5. J Hardman4 and
  6. P Mahoney1
  1. 1Academic Department of Military Anaesthesia and Critical Care, Royal Centre for Defence Medicine, ICT Centre, Birmingham, UK
  2. 2Anaesthesia & Critical Care Research Group, Division of Clinical Neuroscience, Nottingham University Hospital, Queens Medical Centre, Nottingham, UK
  3. 3Defence Science and Technology Laboratories, Salisbury, UK
  4. 4Anaesthesia & Critical Care Research Group, Division of Clinical Neuroscience, Nottingham University Hospital, Queens Medical Centre, Nottingham, UK
  1. Correspondence to Surg Cdr Timothy Scott, The Cornhouse, Poppiefields, Longslow, Market Drayton, TF9 3QY, UK; timscott4{at}me.com

Abstract

Primary blast lung injury frequently complicates military conflict and terrorist attacks on civilian populations. The fact that it occurs in areas of conflict or unpredictable mass casualty events makes clinical study in human casualties implausible. Research in this field is therefore reliant on the use of some form of biological or non-biological surrogate model. This article briefly reviews the modelling work undertaken in this field until now and describes the rationale behind the generation of an in silico physiological model.

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  • Received June 28, 2016.
  • Revision received September 18, 2016.
  • Accepted October 11, 2016.
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Footnotes

  • Contributors TS is the main author and guarantor. EH compiled section on CT analysis. MH, JH compiled section on our current model. EK contributed to section on previous modelling work. PM is the paper originator and main editor.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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