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Reproductive dysfunction and associated pathology in women undergoing military training
  1. Robert M Gifford1,2,
  2. R M Reynolds1,
  3. J Greeves3,
  4. R A Anderson4 and
  5. D R Woods2,5,6,7
  1. 1 British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh, UK
  2. 2 Defence Medical Services, Lichfield, UK
  3. 3 Army Personnel Research Capability, Army HQ, Andover, UK
  4. 4 MRC Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, UK
  5. 5 Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UK
  6. 6 Northumbria and Newcastle NHS Trusts, Wansbeck General and Royal Victoria Infirmary, Newcastle, UK
  7. 7 University of Newcastle, Newcastle upon Tyne, UK
  1. Correspondence to Sqn Ldr Robert M Gifford, British Heart Foundation Centre for Cardiovascular Science, QMRI, Room C3.01, 47 Little France Avenue, Edinburgh EH16 4TJ, UK; r.gifford{at}ed.ac.uk

Abstract

Introduction Evidence from civilian athletes raises the question of whether reproductive dysfunction may be seen in female soldiers as a result of military training. Such reproductive dysfunction consists of impaired ovulation with or without long-term subfertility.

Methods A critical review of pertinent evidence following an extensive literature search.

Results The evidence points towards reduced energy availability as the most likely explanation for exercise-induced reproductive dysfunction. Evidence also suggests that reproductive dysfunction is mediated by activation of the hypothalamic–pituitary–adrenal axis and suppression of the hypothalamic–pituitary–gonadal axis, with elevated ghrelin and reduced leptin likely to play an important role. The observed reproductive dysfunction exists as part of a female athletic triad, together with osteopenia and disordered eating. If this phenomenon was shown to exist with UK military training, this would be of significant concern. We hypothesise that the nature of military training and possibly field exercises may contribute to greater risk of reproductive dysfunction among female military trainees compared with exercising civilian controls. We discuss the features of military training and its participants, such as energy availability, age at recruitment, body phenotype, type of physical training, psychogenic stressors, altered sleep pattern and elemental exposure as contributors to reproductive dysfunction.

Conclusions We identify lines of future research to more fully characterise reproductive dysfunction in military women and suggest possible interventions that, if indicated, could improve their future well-being.

  • SPORTS MEDICINE
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Footnotes

  • Contributors RG undertook the literature search, drafted the manuscript and drew the figures. DW, RR, RA and JG provided editorial input to the manuscript.

  • Competing interests The authors are engaged in planning a prospective study of female endocrine response to UK military training as part of and funded by the UK Defence Women in Ground Close Combat Research Programme.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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