Article Text


The use of creatine supplements in the military
  1. Konstantinos Havenetidis
  1. Correspondence to Professor Konstantinos Havenetidis, Human Performance-Rehabilitation Laboratory, Faculty of Physical & Cultural Education, Hellenic Army Academy, Vari-Koropiou Avenue, Vari, Attiki 16673, Greece; khavenetidis{at}


Introduction Creatine is considered an effective nutritional ergogenic aid to enhance exercise performance. In spite of the publication of several reviews in the last decade on the topic of exercise performance/sports and creatine there is a need for an update related to the military given the lack of information in this area. The aim of this study was to critically assess original research addressing the use of creatine supplements in the military.

Methods A search of the electronic databases PubMed and SPORTDiscus, for the following key words: military personnel, trainees, recruit, soldier, physical fitness, physical conditioning, creatine supplementation, creatine ingestion, nutritional supplements to identify surveys and randomised clinical trials from journal articles and technical reports investigating the effect of creatine supplementation on military populations.

Results Thirty-three out of 90 articles examined the use of creatine as a dietary supplement in military personnel. Twenty-one studies were finally selected on the basis of stated inclusion criteria for military surveys and randomised clinical trials. Most of the surveys (15/17) in the military indicate a high popularity of creatine (average 27%) among supplement users. In contrast, in most of the exercise protocols used (6/9) during randomised clinical trials creatine has produced a non-significant performance-enhancing effect.

Conclusions Creatine is one of the most widely used supplemental compounds in the military. It is not considered a doping infraction or related to any adverse health effects but its long-term usage needs further investigation. Experimental research suggests that creatine supplementation does not enhance physical performance in the military. However, limitations in creatine dosage, military fitness testing and sample group selection might have underestimated the ergogenic properties of creatine. Recent studies also indicate positive effects on various aspects of total force fitness such as cognitive-psychomotor performance, bone health, musculoskeletal damage and neuromuscular function.

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Key messages

  • Creatine has proven to be a popular, legal and safe supplement among military personnel, even though there is little data regarding its long-term effects.

  • The limited experimental research in the military indicates a non-significant performance-enhancing effect during short-term creatine supplementation.

  • Possible potentiating effects of creatine in the military may be masked if guidelines related to dosage, fitness testing and group selection are not implemented.

  • Creatine can become a critical element in the success of military operations requiring rapid rehabilitation periods, high physical cognitive performance, minimal injuries and energy replenishment.

  • Future researchers should evaluate creatine use during longer supplementation periods, exercise bouts simulating various military occupational tasks and more controlled experimental and field studies.


The development of sports science has occurred alongside the development of a myriad of different ergogenic aids aimed at lowering barriers to human athletic performance. Currently, considerable attention is being devoted to the ergogenic properties of the supplement creatine.1

In the military, servicemen in a similar manner to elite athletes, also need to maximise their physical performance in order to meet the physically demanding tasks they perform. During sustained operations, many stress factors are magnified due to sleep deprivation, incomplete exercise recovery, extreme environmental conditions and calorific deficit. Under these circumstances servicemen may seek ‘miracle’ substances that will boost their performance, as failure to complete specific military events for any reason (illness or injury) would not be tolerated.

This article reviews the literature on the use of creatine supplements in the military, addressing the health and ethical issues involved, based on the hypothesis that it is an ergogenic acid which can favourably influence military exercise performance.

Creatine metabolism

Creatine is a nitrogenous organic compound found almost exclusively (98%) in muscle and is primarily synthesised in the liver, but also in the kidneys, pancreas and mammary gland from essential (arginine, methionine) and non-essential (glycine) amino acids.2 When formed, it is released into the bloodstream and transported to muscle tissue against a concentration gradient. The control of muscle creatine concentration is regulated by liver enzymes responsible for creatine synthesis and by creatine and creatinine (anhydro product) levels in the blood which regulate excretion rates3 (Figure 1).

Figure 1

Creatine synthesis and excretion.

Under conditions where food is unavailable, the liver can adjust its metabolism to process compounds released from muscle and other tissues in response to certain hormonal signals. An average carnivorous diet includes 1–2 g of creatine daily which is exclusively provided by meat products such as red and white meat, fish and molluscs; 1 kg of raw meat contains approximately 5 g of creatine.4 However, manipulation of daily creatine intake through diet seems to be a complex procedure since many factors (cooking time, type of meat, muscle site) influence creatine values after ingestion.5

The main function of creatine is to replenish creatine phosphate (CP) which is one of the limiting factors for maintaining the high rate of energy turnover during high intensity exercise. This function can be achieved during recovery periods where creatine acts as an energy transporter between the unlimited energy supplies (fat stores) and the sites where the work is produced (muscles).3 This mechanism was the theoretical background for the suggestion that exogenous creatine could improve CP resynthesis and eventually lead to performance enhancement.

Exercise and creatine supplementation

In the last 20 years substantial scientific evidence has accumulated which demonstrates the beneficial effect of creatine on exercise performance, at least under laboratory conditions where cycle ergometry, treadmill running and isokinetic-isometric dynamometry were used.6–8 Other studies conducted in more representative environments,9 ,10 using various sporting activities showed that performance also improved but to a significantly lower extent. This inconsistency in performance gain has been attributed to differences between studies such as exercise mode, diet, creatine dosage, number and category of participants (responders or non-responders), methods of measurements and statistical analysis.

Despite these issues there are some circumstances under which any potential benefit of creatine supplementation is magnified: a participant’s body mass should show an increase of approximately 5% following the creatine loading phase, as this increase is correlated to an increase of creatine uptake in the muscle11; the recommended exercise protocol should consist of short-term (up to 30 s) maximal-intensity exercise bouts performed in repeated succession1 and the recommended creatine dosage should be within the range of 20–30 g/day for a 5–7-day period (loading phase) followed by a maintenance phase of 2–5 g/day for several weeks.12 Another recommended dosing strategy (relative to body mass) involves 0.03–0.1 g/kg/day for a 28–40-day period.13 The beverage should contain, in addition to creatine, carbohydrate and/or protein for augmenting creatine muscle retention,12 and the recommended creatine regime, totalling 20–30 g/day (loading phase), should comprise small doses (5 g) (4–6 intakes/day) of creatine monohydrate (in powder form) distributed at 2–3 h intervals or 1 g doses (20–30 intakes/day) evenly distributed at 30-min intervals. On each occasion (loading or maintenance phase) powder should be well dissolved in adequate volume of warm water (300–500 mL).14 ,15

The above circumstances, in almost all cases, increase intramuscular creatine content by 10–20% alongside a 2–20% exercise performance enhancement.16 and the proposed mechanisms are listed in Table 1.

Table 1

The mechanism of improved exercise performance from creatine supplementation


To determine potential effects of creatine supplements on military physical performance, MEDLINE (PubMed) and SPORTDiscus were searched for original studies involving military populations (comprising only humans and aged above 19 years old) ingesting exogenous creatine. Search was performed using the terms ‘military personnel’, ‘trainees’, ‘recruit’ and ‘soldier’ with ‘physical fitness’, ‘physical conditioning’, ‘creatine supplementation’, ‘creatine ingestion’, ‘nutritional supplements’. The search for relevant articles contained only the reference lists of journal articles and technical reports. All studies (military surveys and experimental studies) were initially examined. Afterwards, an additional inclusion criterion for military surveys was the citation of creatine, without any other additions (such as ephedra) in the dietary supplement lists. Different inclusion criteria were used for the experimental studies such as minimal washout periods of 28 days or more (cross-over experimental design), creatine dosage higher than 2 g/day for 4 days, random and concealed allocation of subjects to groups, groups of similar abilities, blinding of all subjects-supplements-test administrators. After meeting the aforementioned inclusion criteria a total number of 21 studies were included in the review (Figure 2).

Figure 2

Study selection procedure for data synthesis.


Data from military studies

In the military, physical fitness is emphasised because of its role in military readiness and force health protection. Improving physical fitness is a vigorous and time-consuming procedure where specific exercise, nutrition and sleep guidelines need to be followed. However, current military doctrine requires the ability to maintain round-the-clock operations in order to achieve mission objectives. Under these circumstances military personnel often turn to various ‘unknown’ supplements in order to optimise performance in demanding situations. Table 2 demonstrates the high usage of creatine supplements among various military groups.

Table 2

Recent surveys (1999–2014) on creatine use by military personnel

Most of these surveys have been conducted in the US Army, with a focus on Special Operations Forces (SOF). Several investigators24 ,25 ,27 ,32 who investigated the use of dietary supplements in the US Army Rangers reported that creatine usage was high in this military subpopulation (13–19%), while, others31 ,33 reported even higher usage (26% and 46%) using participants from various groups of SOF (Marines, Rangers). Among the six categories used in that survey,31 (anabolic steroids, amino acids, thermogenics, androstenedione, creatine, protein) creatine supplements were the second most commonly used dietary supplement. In these studies, creatine supplements were consumed by SOF at rates similar to athletic populations possibly because SOF are also intrinsically motivated to maximise their performance. Similar results were also presented by investigators,26 ,28 ,30 ,34 who used large-scale surveys and assessed various non-SOF populations (Army physicians, Administrative Officers-Technicians, Air Force enlisted and officers, active-duty Army personnel). In these surveys creatine was administrated by a high proportion of military personnel (27–33%) and on a regular basis compared with other supplements.

By contrast, other studies29 ,32 have shown that creatine use was not popular (5–6%) among general Army personnel and military National Guard-Reserve participants with Vitamin C and calcium being the most common dietary supplements used (13%).

Apart from US troops, Boos et al,35 in a large observational study of 1017 deployed British servicemen to Iraq reported that 13% of the users preferred creatine among other nutritional supplements. The same investigators36 highlighted the issue and potential concerns regarding the unregulated use of dietary supplements within the British military in Afghanistan; again one of the main types of supplements used by that sample group (n=87) was creatine (34%) surpassed only by protein. Casey et al,37 in a survey comprising various British Army troops (Infantry, Parachute Regiment Units, Royal Armoured Corps, Royal Artillery and Royal Engineers) also reported that creatine was widely consumed (38%) among supplement users.

In one of the surveys conducted,26 creatine users extended the supplementation period (from 4 weeks to 40 weeks) resulting in a 5–10-fold increase in the total recommended creatine ingested. Most of the users relied on popular media such as fitness magazines, rather than nutritionists for information on creatine, suggesting that creatine users, in their pursuit of a performance advantage often follow creatine regimens of questionable efficacy and/or safety. Experimental research in the military about the use of specific supplements is limited, and especially so for creatine ingestion (Table 3).

Table 3

Experimental studies investigating the effect of creatine supplementation on military personnel's exercise performance

In a study,38 conducted in the USA, the role of creatine supplements was assessed in a group of 24 Navy Seals. The researchers measured a series of physiological parameters such as volume of intracellular-extracellular fluid and body fat percentage as well as physical performance (obstacle course passing time). Τhe results showed that the creatine group presented significantly higher intracellular fluid volume but not extracellular or total water volume. Warber et al,40 tested 13 male soldiers performing three consecutive military obstacle course runs followed by a rifle marksmanship task on three occasions each separated by 5 days. The same soldiers also completed a controlled strength test which comprised repeated bench presses (five sets to failure at 70% of one repetition maximum) and answered the Profile of Mood States questionnaire during each test session. Creatine usage (24 g/day for 5 days) significantly improved performance during the controlled strength test by 14% but did not significantly improve military obstacle course performance, marksmanship or mood.

By contrast, Baker-Fulco et al,41 showed no improvement in exercise performance following creatine ingestion. The authors examined whether creatine supplementation improves muscle performance in a group of seven Army recruits during exposure to acute hypobaric hypoxia. The exercise involved submaximal intermittent static knee contractions interspersed with maximal voluntary contractions every minute to exhaustion after supplementation with creatine. There was no effect of creatine on maximal force, muscle endurance, or recovery in normoxia or hypobaric hypoxia but the small number of participants may have affected the statistical analysis. Koenig et al,43 investigated the effect of creatine supplements (25 g/day for 5 days) on repeated static jump performance (two sets of 10 jumps in 60 s) using a group of Army recruits (n=10). The authors demonstrated that creatine supplementation significantly influenced jump height after the sixth bout (p<0.05) and prevented the increasing pattern of fatigue that occurs in repeated jump performance.

Despite the fact that almost all studies demonstrated no beneficial effect of creatine on military exercise performance, further scientific data are required before the military community is fully apprised of the effects of creatine administration. Overcoming previous limitations of small sample group and poor study design, recent studies using non-military groups have confirmed the beneficial effect caused by creatine supplementation on maximal muscle strength-endurance, anaerobic power and speed endurance44–47 using various exercise modes. These studies could be used as a reference for the ‘athlete’ in uniform as maximal strength and power are increasingly being recognised as potentially important components of military fitness.48

However, optimising dosage selection is essential in order to ensure the effectiveness of creatine loading. The amount, form and frequency of creatine ingested should be examined as well as the rate of creatine uptake (via biopsies or excretion in urine) in order to determine the daily creatine gain. If these invasive measurements are not feasible in military populations then a simple monitoring of body weight increase (2–5%) within the first 2–4 days of loading would be an adequate indication of efficient creatine uptake in the muscle. This was mentioned as a limitation in military studies,38 ,40 where no significant differences existed in obstacle course performance following creatine supplementation. Another possible explanation for the negative results in that study40 was probably the use of creatine supplements in the form of sports bars which was not evaluated as thoroughly in relation to creatine uptake in the muscle as other forms such as creatine monohydrate.1

The selection of the military sample group is another issue that might influence the response to creatine supplementation. The recruits in the study of Ensign et al,38 were SOF units who demonstrated smaller insignificant improvement in their performances while, general military populations 40 ,43 showed significant performance potentiation especially in strength abilities. This may be explained by the elite group's (Navy SEALs) intense daily physical training giving elevated creatine levels in the muscle which limits any further increase in intramuscular creatine levels and consequently improvement in exercise performance, which is supported by evidence from elite athletes from various sports who follow intense training where creatine supplementation does not significantly improve exercise performance.9 ,10

It is noteworthy that in aerobic sports, energy is predominately provided by aerobic degradation of carbohydrates (glycolysis) and fat oxidation.49 These procedures provide low and constant energy supply but they do not relate to creatine metabolism. Alternatively, in power sports energy is predominately provided by phosphates (CP, ATP) which are limited, but characterised by high rates of energy supply.50 On this occasion, maintaining high phosphagen levels is heavily dependent on creatine availability which rapidly replenishes CP and consequently ensures the continuation of maximal-intensity exercise. Additionally, during rest periods on an interval-type exercise, creatine serves as an intramuscular high-energy phosphate shuttle between the mitochondria (site of ATP production) and myosin cross-bridge sites that initiate muscular contraction (site of ATP utilisation).51 In that sense, during the most intense and short periods of exercise, the muscle will tax the creatine stores most highly,52 leading to a potentiating effect, following exogenous creatine loading, mainly in short-duration sports involving repeated and sudden bursts of movement (sprints, jumps).

This suggests that the selection of the exercise protocol for evaluating creatine effects on military performance is highly relevant. The obstacle course timings showed insignificant and/or small improvements in the creatine group,38 ,40 possibly because it is dependent on energy sources from anaerobic and aerobic pathways which are less creatine-dependent. Similarly, the use of continuous, submaximal activity (5 km run and 10 km march) in the study of Bennet et al,39 possibly excluded the facilitation of exogenous creatine on energy supply during initiation and/or rest periods due to the predominance of other energy pathways. Marksmanship which was also used as a performance measure in the study of Warber et al,40 was not affected by creatine supplementation, presumably due to the technical rather than the metabolic demands that characterise this military task. Hence, failure to relate the military occupational tasks as well as the appropriate fitness test used with the energetics of creatine metabolism, may limit the validity of the conclusions of these experiments.38–43

Additionally, it is preferable not to use the ‘traditional’ military fitness tests (2 min push-ups, 1 min sit-ups, pull-ups, 2 min curl-ups) since they are not representative indicators of performance of typical, loaded military tasks. Furthermore they impose a systematic bias against larger participants.53 A possibly successful schema would be the use of militarily relevant tests consisting of strength/sprint exercise type such as a timed 400 m run with an 18 kg load, a timed simulated casualty rescue with the fighting load, a repetitive lift and carry, single lift of a weighted ammunition box, a carry task, a fire-manoeuvre sequence and a trench dig.54 ,55 These tests have been shown to be reliable,54 and valid as they simulate common battlefield activities where soldiers sprint to cover and move their body mass and transport wounded soldiers, weapons and/or supplies requiring absolute strength, speed and power.

There is a growing number of studies,18 ,20 ,21 ,56 ,57 which indicate positive effects of creatine supplementation on exercise performance and on several aspects of the health and wellness spectrum. This spectrum currently represents the new approach to fitness in the military called ‘total force fitness’ which seamlessly combines multiple components of fitness in the mind and the body.58 It seems that potentially, several fitness components besides the physical (strength, muscle endurance, speed, power, agility) can be facilitated by creatine supplementation. These include nutritional, medical and psychological components.

One of the goals of nutritional fitness is to establish and meet specific nutritional requirements, a procedure which varies between individuals as in the case of vegetarians, who exclude meat products and consequently creatine from the diet. Since many military missions demand high speed and explosive power, which rely on CP availability, creatine supplementation will provide an alternative method to increase CP stores and consequently maximise nutritional fitness without altering personal dietary habits. It has been reported that individuals with a lower initial level of total muscle creatine content possess higher potential to improve performance in response to creatine supplementation.1 Medical fitness refers to an injury-free, optimal and healthy status where the warfighter is characterised by the highest physiological and psychological readiness.59 Studies18 ,21 indicate that creatine supplementation can be an effective strategy for maximising medical fitness by attenuating the loss in muscle-mass-strength during immobilisation, acting as an effective antioxidant agent after more intense resistance training sessions,1 and improving the force-velocity relationship as well as mean muscle fibre conduction velocity during voluntary and electrically induced contractions.20 These beneficial actions can play a crucial role during short rehabilitation periods in ensuring rapid deployment and/or during long-lasting treatment after serious injuries (blast injuries, bone fractures) and in achieving a full restoration of skeletal and neuromuscular function. Psychological fitness is defined as the integration and optimisation of mental, emotional, and behavioural abilities and capacities in order to optimise performance and strengthen the resilience of warfighters.60 It seems that creatine supplementation can positively influence many aspects of psychological fitness such as awareness, coping, decision making, resilience, burn-out and engagement which are hindered by sleep deprivation and impair the soldiers’ capacity to successfully fulfil their missions. Two studies56 ,57 demonstrated that the creatine-supplemented group presented a substantial resistance to cognitive and psychomotor performance deterioration (choice reaction time, balance, number of errors) as well as in mood swings in individuals suffering from 24-h sleep deprivation. However, there is still a need for targeted research with greater representation among military groups and the use of a plethora of military occupational tasks in order to quantify any potential benefits of creatine and minimise any clinical risks.

Health and ethical issues

Most anecdotal reports of side effects have described an increased incidence of dehydration or muscle cramping or gastrointestinal distress,61 ,62 especially in athletes who exercise in hot and humid environments. These potential side effects were based on athletic media reports in the late 1990s, were never supported by clinical evidence and the athletes did not report a consistent pattern of ‘perceived’ negative side effects as a result of the creatine-supplementation protocol.63 A recent meta-analysis found no evidence to support the concept that creatine supplementation either hinders the body's ability to dissipate heat or negatively affects the athlete's body fluid balance.64 In fact, in most of the studies it was demonstrated that creatine ingestion may actually have promoted hydration, and reduce thermal stress during exercise in the heat.11 ,63 ,65–68

Other studies have also demonstrated that creatine ingestion has no negative effects on renal, hepatic, cardiac or muscle function.69–72 Furthermore, the incidence of human adverse reactions is limited and not necessarily linked to creatine itself, but rather to violation of the creatine supplementation protocols for potentially greater enhancement.69 However, one of the greatest concerns about creatine use is that few authors have examined its long-term effects on users’ health. Kim et al,73 suggested that exogenous creatine in quantities greater than 3–5 g/day is considered to apply a heavy load on kidney function and should not be used by individuals with pre-existing renal disease or those with a potential risk of renal dysfunction such as diabetes, hypertension or reduced glomerular filtration rate. Considering that in the loading phase a typical creatine regime includes 20–25 g/day, this high quantity combined with a long supplementation period can potentially cause a cumulative detrimental effect on users’ renal health. Additionally, military groups such as SOF units operating under hot and humid conditions for long periods while carrying heavy loads74 may magnify potential adverse health effects of creatine which are considered negligible in athletes who participate in controllable short-term exercise trials.

The evidence supports the advice that creatine users should not: become hypohydrated during exercise,15 ,75 with reductions in water intake less than 1.5–2 L/day, ingest creatine doses more than 20–25 g/day and 5–7 g/day for the loading and maintenance phase, respectively,76 extend the supplementation period longer than 7 days and 120 days for the loading and maintenance phases, respectively,77 and follow strenuous exercise protocols under hot environmental conditions for extended time periods, since no authors have examined the long-term effects of creatine on thermoregulation.64 Considering that the mechanisms of creatine action are incompletely understood and therefore, the long-term clinical safety cannot be guaranteed, these guidelines may serve as a means of health prevention measures. Furthermore, annual training plans need to be designed by military professionals which will embody scientific methodology by the use of periodisation models, acclimatisation techniques and nutritional support in order to avoid health problems in military servicemen caused by intense training and not by creatine per se. There is also concern about the synergistic or antagonistic role of creatine in relation to other supplements such as caffeine,78 vitamins,79 as well as the potential risks that might emerge from its frequent mixture with unknown substances.80 These phenomena underscore the conduction of recent surveys by the military management where the efficacy and safety of various forms of creatine will be assessed based on its interaction with other supplements/pharmaceuticals.

In relation to the ethical aspect of creatine supplementation on military populations, it must be noted that currently it does not appear on the International Olympic Committee's list of banned substances, while some ergogenic aids are banned by sporting governing bodies due to their detrimental effects on athletes’ health, while others are deemed to confer what is seen to be an unfair advantage. These considerations might raise the ethical question as to whether the use of creatine should be banned above specific concentration levels, based on its ergogenic effect akin to the former ban on caffeine which is a normal dietary component. Such a prohibition would be difficult to enforce due to the difficulties in detecting creatine turnover because it is produced naturally by the body and is part of any normal meat-containing diet; even with the use of repeated muscle biopsies (which is not feasible in military populations) this prohibition might end up punishing servicemen who are at the top of the biological range in terms of muscle creatine levels.


Although research on creatine involved early experimental contributions on such diverse topics as high-energy compounds, urinary constituents and diagnosis of myocardial infarctions, this simple compound has not yet, after 150 years, yielded all its secrets. Despite the relatively short time of investigation considerable published research indicates that creatine ingestion is a new ergogenic aid to enhance exercise performance. This review has provided some insight into the use of creatine supplements by military personnel, the effects on military exercise performance, the methodology involved in the few experimental studies performed and how this methodology affected the participants’ abilities under baseline/placebo and creatine conditions. A series of military surveys have clearly shown that creatine has rapidly become one of the most popular, legal and safe supplements among military personnel, even though there is little data, regarding its long-term effects.

The limited experimental research also suggests that short-term creatine supplementation is not related to a significantly enhanced physical performance in the military. It seems that possible potentiating effects in the military may be masked if specific guidelines are not followed in terms of creatine dosage, military fitness testing and sample group selection. Under these circumstances, the possibility that creatine supplementation may enhance military exercise performance should be investigated further, in order to allow data to be applicable and compatible with the new holistic doctrine for military fitness.

  • Received December 22, 2014.
  • Revision received March 4, 2015.
  • Accepted March 8, 2015.
View Abstract


  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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