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Furosemide in the Treatment of Phosgene Induced Acute Lung Injury
  1. C Grainge1,2,
  2. Mr Adam Smith1,
  3. BJ Jugg1,
  4. SJ Fairhall1,2,
  5. T Mann1,
  6. R Perrott1,
  7. J Jenner1,
  8. T Millar3 and
  9. P Rice1
  1. 1Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire
  2. 2Royal Centre for Defence Medicine, Birmingham
  3. 3University of Southampton
  1. Biomedical Sciences Department, Dstl Porton Down, Salisbury SP4 OJQ, UK +44 1980 614695 +44 1980 613741 ajsmithg{at}dstl.gov.uk

Abstract

Method Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg-1), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg.ml-1 solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure.

Results Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment.

Conclusion Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure.

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