Eight patients suffering from cutaneous leishmaniasis acquired in Belize were treated with 800 mg oral ketoconazole daily for 28 days . Four were infected with Leishmania mexicana mexicana and four with Leishmania braziliensis braziliensis. On complelion of therapy, all cases of Leishmania mexicalla mexicana infection and one of Leishmania braziliensis braziliensis infection showed significant clinical improvement. No side-effects were observed during this study which suggests that ketoconazole might be a safe and effective form of therapy for cutaneous leishmaniasis caused by Leishmania mexicona mexicana.
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